Could the average male or a male who lift weights regularly take out a female MMA fighter?
It would depend on the female MMA fighter since there is a very wide discrepancy in size, skillset, ability, etc., even at the UFC level. Let's assume you're talking about one of the sport's big name fighters, like current two-division champion Amanda Nunes.
Nunes is 5′8″ and weighed in at 145 pounds for her recent fight with Cris Cyborg. I couldn't find any data on her body fat percentage, but it's obviously quite low for a female, probably in the 14–20% range.